Development of a Vaccine Platform for African Horse Sickness Virus Using a Synthetic Biology Approach
This project aims to exploit synthetic biology and established molecular methods to develop a universal vaccine platform that can be rapidly deployed against any African Horse Sickness Virus (AHSV) serotype. Project activities include: 1) developing a Reverse Genetics (RG) system for the genetic manipulation of AHSV; 2) using RG to rapidly generate seed viruses for the production of a universal AHSV vaccine platform based on inactivated “synthetic” viruses; 3) producing the “synthetic” vaccines in a vaccine manufacturer setting; 4) determining their ability to induce neutralizing antibodies in experimental animal models; 5) determining their ability to induce neutralizing antibodies in natural host; and 6) determining their ability to elicit adequate protective immunity in the natural host.
Providers and Implementers ?
|Implementer||Istituto Zooprofilattico Sperimentale (IZS)||State|
|Implementer||University of Glasgow (Scotland)||NGO|
Related Projects & Programs
|Mr Claudio Martinello||Deputy Head of Office||
Disarmament, Arms Control, and Non-Proliferation