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Project

Development of a Vaccine Platform for African Horse Sickness Virus Using a Synthetic Biology Approach

This project aims to exploit synthetic biology and established molecular methods to develop a universal vaccine platform that can be rapidly deployed against any African Horse Sickness Virus (AHSV) serotype. Project activities include: 1) developing a Reverse Genetics (RG) system for the genetic manipulation of AHSV; 2) using RG to rapidly generate seed viruses for the production of a universal AHSV vaccine platform based on inactivated “synthetic” viruses; 3) producing the “synthetic” vaccines in a vaccine manufacturer setting; 4) determining their ability to induce neutralizing antibodies in experimental animal models; 5) determining their ability to induce neutralizing antibodies in natural host; and 6) determining their ability to elicit adequate protective immunity in the natural host.

Risk Area(s) covered

Biological

Activities

Emergency Preparedness/Response

Beneficiary Countries

United Kingdom

Beneficiary Regions

Europe

Budget

143990 EUR

Status

Active
Start Date: January 1, 2017
End Date: 

ASI Database Release

Providers and Implementers ?

Related Projects & Programs

Contacts

Name Position Agency/Department/Org Note
Mr Claudio Martinello Deputy Head of Office
Disarmament, Arms Control, and Non-Proliferation
Italy

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